Other than in the early phase of irritable bowel disease, the place in therapy of antispasmodics is questionable. Reassurance, diet, fluids, exercise, bulking agents and lifestyle modifications achieve best results
In April 2014, following a Europe-wide review, the MHRA issued advice to healthcare professionals relating to the use of domperidone, restricting its use to relief or nausea and vomiting, advising that it should be used at the lowest effective dose for the shortest possible time, and highlighting changes to the contraindications, dosing and duration of treatment of the medicine.
The full advice from the MHRA can be accessed here.
Restrictions: Excludes modified-release preparations
Where possible, the tablets should be used as the oral suspension is significantly more expensive
Restrictions: Restricted to initiation by, or on advice of, a specialist.