NHS Greater Glasgow & Clyde Area Drug and Therapeutics Committee
Greater Glasgow and Clyde Prescribing
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4 Central nervous system

4.6 Drugs used in nausea and vertigo

Preferred list
DOMPERIDONE

Prescribing Notes:

In April 2014, following a Europe-wide review, the MHRA issued advice to healthcare professionals relating to the use of domperidone, restricting its use to relief or nausea and vomiting, advising that it should be used at the lowest effective dose for the shortest possible time, and highlighting changes to the contraindications, dosing and duration of treatment of the medicine.

The full advice from the MHRA can be accessed here.

 

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3429.htm

METOCLOPRAMIDE

Prescribing Notes:

  • Metoclopramide causes more frequent extra-pyramidal side effects than domperidone and is not indicated in patients less than 20 years of age except for limited indications when the dose should be determined on the basis of body weight.
  • Metoclopramide should only be prescribed for short-term use (up to 5 days)
  • It should not be used in children below 1 year of age
  • It should only be used in children over 1 year as second-choice treatment for prevention of delayed nausea and vomiting after chemotherapy and for post-operative nausea and vomiting

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3431.htm

ONDANSETRON (tablets, injection, oral solution)

Prescribing Notes:

For other available Formulary formulations, see Total Formulary entry below.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3443.htm

Total Formulary
CYCLIZINE

Restrictions: Restricted to specialist initiation only.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3404.htm

PROMETHAZINE

Restrictions: Restricted to specialist initiation only.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3410.htm

CHLORPROMAZINE

Restrictions: Restricted to specialist initiation only.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3413.htm

GRANISETRON

Restrictions: Restricted to specialist initiation only. Prevention of nausea and vomiting associated with moderately or highly emetogenic chemotherapy is restricted to use in accordance with regional protocol. In the management of post-operative nausea and vomiting (PONV), restricted to use in patients refractory to routine antiemetics or with a substantial history of PONV. The transdermal patch preparation is only for use where oral administration is not appropriate because of swallowing difficulties.

Prescribing Notes:

Prolonged use can cause severe constipation and routine laxatives should be considered.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3441.htm

NABILONE

Restrictions: Restricted to specialist initiation only.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/3448.htm

APREPITANT

Restrictions: Restricted to use in accordance with regional CINV guideline. The prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy is not recommended by SMC and remains non-formulary.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/128408.htm

FOSAPREPITANT (IVEMEND)

Restrictions: Restricted to use according to local protocol for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based cancer chemotherapy in adults.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/200971.htm

DROPERIDOL (XOMOLIX) (injection)

Restrictions: Restricted to use by consultant anaesthetists for use as a third line antiemetic for PONV in patients with previous failure of other formulary agents. This preparation should only be routinely held in theatre recovery areas for this indication. The use of droperidol for addition to a PCA containing opiates remains non-Formulary.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/202671.htm

NETUPITANT WITH PALONOSETRON (AKYNZEO) (capsules)

Restrictions: Restricted to specialist use for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based cancer chemotherapy. Refer to the regional antiemetic policy.

ONDANSETRON (orodispersable films)

Restrictions: Restricted to specialist initiation in patients with an enhanced risk of aspiration or who experience difficulties in swallowing for the inidcations listed below.

Prescribing Notes:

  • Prophylaxis of acute nausea and vomiting induced by moderately emetogenic chemotherapy.
  • Prophylaxis and treatment of delayed nausea and vomiting induced by moderately to highly emetogenic     chemotherapy.
  • Prophylaxis and treatment of acute and delayed nausea and vomiting induced by highly emetogenic radiotherapy.
  • Prophylaxis and treatment of post-operative nausea and vomiting (PONV).

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/PHP2561-ondansetron.htm