NHS Greater Glasgow & Clyde Area Drug and Therapeutics Committee
Greater Glasgow and Clyde Medicines
Medicines Update

How to activate the Inhixa® needle guard

Reminder re how to activate the Inhixa® needle guard

Currently within NHSGGC acute sector we are using the new Inhixa® brand of enoxaparin 20 mg and 40 mg pre-filled syringes.  Inhixa® is regarded as a “biosimilar” medicine to Clexane® and is considered clinically equivalent.

Since introduction of Inhixa® there have been a few reports of needlestick injury.  Anyone responsible for administering enoxaparin should ensure that they are aware of the difference in how the Inhixa® safety needle operates.

It is also important to ensure that any patient self-administering Inhixa®, can operate the Inhixa® safety device. If a patient is unable to use Inhixa®, advice can be sought from a clinical pharmacist regarding alternative products for that patient. Please ensure that the required brand of enoxaparin is highlighted on the discharge prescription.

Unlike Clexane®, the Inhixa® safety device does not automatically activate. After administration of Inhixa® the user must apply additional pressure to the plunger to activate the needle guard until an audible click is heard. This is explained further in the manufacturer’s Patient Information Leaflet and in a short video provided by the manufacturer. Search for Inhixa® on YouTube and refer to the ‘INHIXA’ video. The manufacturer has also supplied some “dummy” syringes and some “How to Inject” leaflets. Please contact Medicines Information if you require a supply of these (0141 211 4407 or email Medinfo@ggc.scot.nhs.uk).

In addition, a drug alert advising ‘caution in use’ has been disseminated by the MHRA re Inhixa®.  This relates to rare cases of premature self-activation of the safety device in unused, unopened pre-filled Inhixa® syringes.  When premature activation has occurred, administration is not possible.  Further information is available here.


Published 03/05/18