NHS Greater Glasgow & Clyde Area Drug and Therapeutics Committee
Greater Glasgow and Clyde Medicines
Medicines Update

Novel psychoactive substances: acute and chronic harms

Novel Psychoactive Treatment UK Network (NEPTUNE) was developed to improve clinical practice in the management of harms resulting from the use of club drugs and novel psychoactive substances. It is aimed at clinicians working in a range of frontline settings, including drug treatment and recovery services, emergency departments, sexual health services and primary care.


With the support of a multi-disciplinary group of experts, clinical guidance has been developed based on a systematic review of the evidence and clinical consensus. There are sections covering club drugs and novel psychoactive substances (including “legal highs”) such as gamma hydroxybutyrate (GHB), ketamine, nitrous oxide, cocaine and derivatives, amphetamine type substances, mephedrone, ecstasy, hallucinogenic drugs and synthetic cannabinoids.