NHS Greater Glasgow & Clyde Area Drug and Therapeutics Committee
Greater Glasgow and Clyde Medicines
Medicines Update

Mirabegron and severe hypertension

Following reports of severe hypertension including hypertensive crisis associated with cerebrovascular and cardiac events, the MHRA have announced that mirabegron is now contraindicated in patients with severe uncontrolled hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg, or both). It should be used with caution in patients with systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg.


Regular monitoring of blood pressure is important, especially in patients with pre-existing hypertension. Please report suspected side effects to mirabegron on a Yellow Card.


The recently published Medicines Update Extra bulletin has more information on management of urinary incontinence and overactive bladder