NHS Greater Glasgow & Clyde Area Drug and Therapeutics Committee
Greater Glasgow and Clyde Medicines
Medicines Update

Creon 40 000 Unavailable

The manufacturer of Creon® (pancreatin) has advised that patients currently prescribed the 40 000 strength are likely to have difficulty obtaining it from mid April 2015. There is no indication when it will be available again.

 

Pancreatin is a biological product and lower than expected yields of high-potency enzymes from porcine glands has impacted on the current availability of Creon 40 000. This issue does not affect the lower dose Creon 25 000 and 10 000 products which remain available. It is recommended that an equivalent dose of a lower strength be prescribed. Using Creon 25 000 will reduce the number of capsules required compared to use of the 10 000 product.

 

Creon 25 000 is just over half the strength of Creon 40 000 so the usual dose should be approximately doubled as a starting point. As with all changes to pancreatin usage, dosage should be adjusted according to size, number and consistency of stools so that the patient thrives.

 

Current Creon 40 000 dose

(number of capsules)

Approximate Creon 25 000 dose

(number of capsules)

Equivalent Creon 10 000 dose

(number of capsules)

1

2

4

2

3

8

3

5

12

4

7

16

5

8

20

6

10

24